Profile

• 16th November, 2022: Associate Professor of Surgery/Reader in Endocrine Surgery (Docent), Faculty of Medicine and Health, Örebro University, Örebro, Sweden
• 01 September 2020 - 31 June 2021: Post-doc Research Fellow Faculty of Medicine and Health, Örebro University, Sweden
• 01 January 2019-31 December 2020: Post-doc Research Fellow ENETS CoE for Neuroendocrine Tumors, National and Kapodistrian University of Athens, Greece
• 28 May 2015: Specialty Certification in Endocrine Surgery Fellow of the European Board of Surgery, (FEBS-Endocrine), European Board of Surgery Qualification (EBSQ/UEMS)
• 5 April 2013:  Specialty Certification in Surgery, Swedish National Board of Health
• 25 May 2007: Exercise Permit of Medical Profession, Swedish National Board of Health
• MD
  University of Crete, Faculty of Medicine, Heraklion, Greece  20 July 2004
  Undergraduate clinical rotation:
  Massachusetts General Hospital, Harvard Medical School and Tufts-New England Medical Center, Tufts University School of Medicine, Boston, USA
  Louis Pasteur University, Strasbourg, France

 

 

From March 2014 to December 2017: Doctoral Thesis: “Small Intestinal Neuroendocrine Tumors: Clinical Studies, Novel Serum Biomarkers and Sensitivity to Cytotoxic and Targeted Agents.”, Institution of Surgical Sciences, Uppsala University, Sweden

 

• 15 October 2021-Present: Consultant General and Endocrine Surgeon, 2nd Department of Surgery, Red Cross Hospital “Korgialenio-Mpenakio”, Athens, Greece,
• 1 November 2019-14 October 2021: Senior Consultant General and Endocrine Surgeon Breast-Endocrine Section, Department of Surgery, Örebro University Hospital, Örebro, Sweden
• 5 April 2013-31 October 2019: Staff Surgeon (Specialist), Endocrine Section, Department of Surgery, Uppsala University Hospital, Uppsala, Sweden
• 1 November 2012-28 February 2013: Clinical Fellow, Trauma Center, Tygerberg Academic Hospital, University of Stellenbosch Capetown, South Africa
• 1 March 2009-31 October 2012: Resident in General Surgery, Department of Surgery, Uppsala University Hospital, Uppsala, Sweden
• 1 November 2007-30 January 2009: Resident in General Surgery, Department of Surgery, Gävle County Hospital, Gävle, Sweden
• 1 February 2009-28 February 2009: Volunteer physician Day Surgery Section, Holy Cross Orthodox Hospital, Kampala, Uganda
• 01 June 2006-28 February 2007: Hellenic Med Corps Officer Chios, Greece
• 1 November 2004-31 April 2006: Internship,Rethimnon County Hospital- Health Center of Perama, Greece
  

• Thyroid Surgery
• Comprehensive Neck Dissection for Thyroid Cancer
• Minimally Invasive Parathyroid Surgery
• Parathyroid Neck Exploration
• Minimally Invasive Laparoscopic and Retroperitoneoscopic Adrenal Surgery
• Laparotomy for Adrenocortical Carcinoma
• Abdominal Surgery for Gastroenteropancreatic Neuroendocrine Tumors
  

• European Neuroendocrine Tumor Society (ENETS) Center of Excellence Research/ Training International Fellowship, 2020
• Royal Swedish Academy of Sciences Scholarship for “Epidemiological and Clinical Studies in Gastroenteropancreatic Neuroendocrine Tumors”, 2020
• Postodoctoral Research Scholarship, Örebro University, 2020
• Swedish Society of Medicine Postdoctoral Scholarhip for “Translational and Clinical Studies in Neuroendocrine Tumors”, 2020
• Gastroenterologic Travel Award, Swedish Society of Medicine 2018
• Best Clinical Tutor Award, Uppsala University 2017
• Johan Westerdahls Scholarship Award, Swedish Endocrine Society, 2017
• The Lennanders Scholarship Award, Uppsala University, 2017
• IPSEN Travel Award, Swedish Endocrine Society, 2016

   

Original articles and Meta-analyses

1. Daskalakis K, Tsoli M, …, Kaltsas G. Longitudinal Changes in Ki-67 Indices in Small-Intestinal Neuroendocrine Tumours and Their Impact on Survival. Neuroendocrinology 2024
2. Wedin M, Janson ET, …, Daskalakis K. Prevalence of metastases outside the liver and abdominal lymph nodes on 68Ga-DOTATOC-PET/CT in patients with small intestinal and pancreatic neuroendocrine tumours.  J Neuroendocrinol 2024:36(5): e13391.
3. Daskalakis K, Tsoli M, …, Kaltsas G. Modified Histopathological Grading Optimizes Prediction of Survival Outcomes in Small Intestinal Neuroendocrine Tumours. J Clin Endocrinol Metab 2024
4. Lind P, Nordenström E, …, Daskalakis K. Impact of fine-needle aspiration cytology in thyroidectomy extent and associated surgical morbidity in thyroid cancer. Langenbecks Arch Surg 2024:409(1):68.
5. Tsoli M, Daskalakis K, …, Kaltsas G. Pancreatic metastases in patients with neuroendocrine neoplasms: A multi-centre cohort study. J Neuroendocrinol 2023:35(4):e13269.
6. Nesti C, …, Daskalakis K, Frilling A, Garcia-Carbonero R, Grozinsky-Glasberg S, Hernando J, Hervieu V, Hofland J, Holmager P, Inzani F, Jann H, Jimenez-Fonseca P, Kaçmaz E, Kaemmerer D et al [ Klimacek B Nr. 32 ]. Hemicolectomy versus appendectomy for patients with appendiceal neuroendocrine tumours 1-2 cm in size: a retrospective, Europe-wide, pooled cohort study. Lancet Oncol 2023
7. Meta-analysis of placebo-arm dropouts in osteoporosis randomized-controlled trials and implications for nocebo-associated discontinuation of anti-osteoporotic drugs in clinical practice. Kravvariti E, Kasdagli MI, Diomatari KM, Mouratidou P, Daskalakis K, …, Yavropoulou MP. Meta-analysis of placebo-arm dropouts in osteoporosis randomized-controlled trials and implications for nocebo-associated discontinuation of anti-osteoporotic drugs in clinical practice. Osteoporos Int 2023
8. Daskalakis K, Wedin M, .., Kaltsas G. Association of lymph node metastases, grade and extent of mesenteric lymph node dissection in locoregional small intestinal neuroendocrine tumors with recurrence-free survival. J Neuroendocrinol 2022:34(11):e13205.
9. Wedin M, Tsoli M, .., Daskalakis K. Heterogeneity of Small Intestinal Neuroendocrine Tumors Metastasis - Biologic Patterns of a Series with Virchow's Node Involvement. Cancers (Basel) 2022:14(4)
10. Kaçmaz E, Engelsman AF, Bemelman WA, Tanis PJ, Nieveen van Dijkum EJM; International Study Group of Small bowel neuroendocrine neoplasm Surgery (ISGSS). International survey on opinions and use of minimally invasive surgery in small bowel neuroendocrine neoplasms.  Eur J Surg Oncol 2022:48(6):1251-1257.
11. Aktypis C, Spei ME, …, Daskalakis K. Cardiovascular Toxicities Secondary to Biotherapy and Molecular Targeted Therapies in Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Cancers (Basel). April 2021.
12. Alevroudis E, Spei ME, …, Daskalakis K. Clinical Utility of 18F-FDG PET in Neuroendocrine Tumors Prior to Peptide Receptor Radionuclide Therapy: A Systematic Review and Meta-Analysis. Cancers (Basel). April 2021.
13. Wedin M, Mehta S, …Daskalakis K. The Role of Serum 5-HIAA as a Predictor of Progression and an Alternative to 24-h Urine 5-HIAA in Well-Differentiated Neuroendocrine Neoplasms. Biology (Basel). January 2021
14. Tsoli M, Spei ME, … Daskalakis K. Association of a Palliative Surgical Approach to Stage IV Pancreatic Neuroendocrine Neoplasms with Survival: A Systematic Review and Meta-Analysis. Cancers (Basel). August 2020.
15. Alexandraki KI, Kaltsas G, … Daskalakis K. The Effect of Prophylactic Surgery in Survival and HRQoL in Appendiceal NEN. Endocrine. June 2020
16. Daskalakis K, Alexandraki KI, Kloukina I et al. Increased autophagy/ mitophagy levels in primary tumours of patients with pancreatic neuroendocrine neoplasms. Endocrine. February 2020
17. Tsoli Μ, Alexandraki ΚΙ, ... Daskalakis Κ. Anti-tumor Activity and Safety of Multikinase Inhibitors in Advanced and/or Metastatic Thyroid Cancer: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials. Hormone and Metabol Res. October 2019 18. Tsolakis AV, Ragkousi A, ...Daskalakis K. Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis. World J Gastroenterol. Sep 2019
19. Daskalakis K, Alexandraki K, Kassi E et al. The risk of lymph node metastases and their impact on survival in patients with appendiceal neuroendocrine neoplasms: a systematic review and meta-analysis of adult and paediatric patients. Endocrine. Sep 2019
20. Daskalakis K, Tsoli M, Alexandraki K et al. Magnetic Resonance Imaging or Endoscopic Ultrasonography for detection and surveillance of Pancreatic Neuroendocrine Neoplasms in patients with Multiple Endocrine Neoplasia type 1? Hormone and Metabol Res. Jul 2019.
21. Daskalakis K, Tsoli M, Karapanagioti A, Recurrence and metastatic potential in Type 1 gastric neuroendocrine neoplasms.Clin Endocrinol (Oxf). Jul 2019.
22. *Daskalakis K, *Chatzellis E, *Angelousi A et al. Activity and safety of standard and prolonged capecitabine/temozolomide administration in patients with advanced neuroendocrine neoplasms. (*equal contribution) Neuroendocrinology. June 2019
23. Daskalakis K, Tsoli M, Angelousi A et al. Anti-tumour activity of everolimus and sunitinib in neuroendocrine neoplasms. Endocrine Connections, April 2019.
24. Daskalakis K, Tsoli M, Srirajaskanthan R et al. Lung Metastases in Patients with Well-Differentiated Gastroenteropancreatic Neuroendocrine Neoplasms: An Appraisal of the Validity of Thoracic Imaging Surveillance. Neuroendocrinology, Jan 2019.
25. Daskalakis K, Chatzelis E, Tsoli M et al. Endocrine Paraneoplastic Syndromes in patients with Neuroendocrine Neoplasms. Endocrine, Oct 2018.
26. Daskalakis K, Kaltsas K, Öberg K et al. Lung Carcinoids: long-term surgical results and the lack of prognostic value of Somatostatin Receptors and other novel IHC markers. Neuroendocrinology, Sept 2018.
27. Daskalakis K, Norlén O, Karakatsanis A et al. Activity ex vivo of cytotoxic drugs and targeted agents in Small Intestinal NETs. Endocr Relat Cancer Feb 2018.
28. Daskalakis K, Karakatsanis A, Hessman et al. Association of Prophylactic Surgical Approach to Stage IV Small Intestinal Neuroendocrine Tumors with Survival. JAMA Oncology Oct 2017.
29. Karakatsanis A, Daskalakis K, Stålberg P et al. The routine use of Super Paramagnetic Iron Oxide nanoparticles as the sole method for Sentinel Node Biopsy in patients with breast cancer. The MONOS study. British J Surg Nov 2017.
30. Daskalakis K, Karakatsanis A, Norlen O et al. Clinical signs of fibrosis in small intestinal neuroendocrine tumours. British J Surg. Jan 2017.
31. *Daskalakis K, *Edfeldt K, Bäcklin C et al. DcR3, TFF3 and Midkine are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors (*equal contribution). Neuroendocrinology Nov 2016.
32. Karakatsanis A, Christiansen PM, … Daskalakis K… et al. The Nordic SentiMag trial: a comparison of super paramagnetic iron oxide (SPIO) nanoparticles versus Tc (99) and patent blue in the detection of sentinel node (SN) in patients with breast cancer and a meta-analysis of earlier studies. Breast Cancer Res and Treat. E-pub Apr 2016.
33. Norlen O, Daskalakis K, Oberg K et al. Indication for liver transplantation in young patients with small intestinal NETs is rare? World J Surg. Nov 2014.

Review articles (peer reviewed)

34. Koumarianou A, Daskalakis K, …, Pavel M. Efficacy, safety and unmet needs of evolving medical treatments for carcinoid syndrome. J Neuroendocrinol 2022:34(7):e13174.
35. Tsoli M, Daskalakis K, …, Tsolakis A. A Critical Appraisal of Contemporary and Novel Biomarkers in Pheochromocytomas and Adrenocortical Tumors. Biology (Basel) 2021:10(7)
36. Daskalakis K. Functioning and non-functioning pNENs. Current Opinion in Endocrine and Metabolic Research. 2021 April.
37. Alexandraki KI, Spyroglou A, Kykalos S, Daskalakis K et al. Changing biological behaviour of NETs during the evolution of the disease: progress on progression. Endocr Relat Cancer. 2021 April.
38. *Daskalakis K, *Machairas N,.. Sotiropoulos GC. Currently available treatment options for neuroendocrine liver metastases (*equal contribution). Annals of Gastroenterology. Jan 2021
39. Koumarianou A., Alexandraki KI,, ..Daskalakis K. Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocrine Neoplasms: A Systematic Review. Journal of Clinical Medicine. June 2020
40.*Daskalakis K., *Alexandraki KI, Tsoli M et al. Endocrinological Toxicity Secondary to Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) (*equal contribution). Trends in Endoncrinology and Metabolism. Dec 2019
41. Daskalakis K, Juhlin C, Påhlman L et al. The use of pre- or post-operative antibiotics in surgery for appendicitis. A systematic review. Scand J Surg Sept 2013

Other (book chapter/editorial/letter to the editor)

42. Hellman, P., Norlén, O., Stålberg, P., Daskalakis, K. (2024). Thyroid Cancer. In: Yalcin, S., Öberg, K. (eds) Neuroendocrine Tumours. Springer, Cham. https://doi.org/10.1007/978-3-031-56968-5_22
43. Chatzellis E, Daskalakis K, Angelousi A et al. Authors' response to the letter "Temozolomide-Capecitabine (TemCap) chemotherapy for Neuroendocrine Neoplasms (NENs): the dilemma of treatment duration" by Lamarca et al. regarding the original manuscript "Activity and Safety of Standard and Prolonged Capecitabine/Temozolomide Administration in Patients with Advanced Neuroendocrine Neoplasms." Neuroendocrinology. Oct 2019
44. Daskalakis K, Norlén O, Hellman P. Applying the use of novel biomarkers for neuroendocrine tumors in the clinic: where are we now? Int J Endo Oncol, Feb 2019.
45. Daskalakis K, Tsolakis AV. Up-front Surgery of Small Intestinal Neuroendocrine Tumors. Time to reconsider? World J Gastroenterol. Aug 2018.
46. Daskalakis K, Tsolakis AV. Is there a place for systemic chemotherapy and targeted agents in metastatic Small Intestine Neuroendocrine Tumors? Journal of Clinical Gastroenterology and Digestive Disorders, Aug 2018.
47. Daskalakis K. Adrenal tumors and paragangliomas. Much new - and now? Svensk Kirurgi Oct 2016

Societies

• Neuroendocrine Tumor Society (ENETS)
• European Society of Endocrine Surgeons
• Greek Society of Endocrine Surgery
• Swedish Society of Endocrine Surgery
• Swedish Surgical Society Swedish
• Medical Association of Athens, Greece

Editorial Board

• Scientific Reports-Nature
• Frontiers in Endocrinology
  

 

1.    Principal investigator and PhD supervisor in the following research projects at Örebro University, Örebro, Sweden:

A.    ”Epidemiological and Clinical Studies in Gastroenteropancreatic Neuroendocrine Tumors (NETs)” (https://www.researchweb.org/is/fourol/project/273548)
B.    ”Epidemiological and Clinical Studies in Thyroid Cancer in Sweden - Role of Preoperative Thyroid Cytology and Management of non Well-differentiated Cancer types”, (https://www.researchweb.org/is/en/fourol/project/275115)
C.    “Lithium-associated hyperparathyroidism— a randomized trial, disease follow-up and quality of life aspects”

2.    Affiliated Researcher and Co-PhD supervisor at at EKPA-Laiko ENETS (European Neuroendocrine Tumor Society) Center of Excellence for NETs, National and Kapodistrian University of Athens, Greece.
A.    “Clinical and translational studies of patients with Multiple Endocrine Neoplasia Type 1”
B.    ”Clinical Studies in Small Intestinal Neuroendocrine Tumors; Collaborative project from ENETS Centers of Excellence for NETs”

3.    Member of the European MEN1 Task Force within ENETS with ongoing research project on Multiple Endocrine Neoplasia type
“Survival outcomes of familiar pancreatic NETs with metastatic disease within MEN1”